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| Гайвер1 | Дата: Среда, 13.01.2010, 01:58 | Сообщение # 1 |
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| Безкоштовна консультація. З задоволенням дам усі відповіді на усі Ваші запитання.
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| sweesaupeZH | Дата: Четверг, 26.12.2013, 18:29 | Сообщение # 2 |
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| SusswessyG | Дата: Понедельник, 30.12.2013, 23:57 | Сообщение # 3 |
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| Tergororjer | Дата: Четверг, 09.04.2015, 18:19 | Сообщение # 4 |
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| famuyiyaoj | Дата: Четверг, 09.04.2015, 18:49 | Сообщение # 5 |
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Группа: Гости
| Varenicline (trade mention Chantix in the USA and Champix in Canada, Europe and other countries, marketed next to Pfizer, usually in the shape of varenicline tartrate), is a prescription medication habituated to to treat nicotine addiction. Varenicline is a nicotinic receptor unfair agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this characteristic it is similar tocytisine and distinct from the nicotinic contender, bupropion, and nicotine replacement therapies (NRTs) like nicotine patchesand nicotine gum. As a affinity to agonist it both reduces cravings seeking and decreases the pleasurable effects of cigarettes and other tobacco products. Inclusive of these mechanisms it can work for some patients to discharged smoking.
Medical uses
Varenicline is indicated for smoking cessation. In a 2006 randomized controlled bother sponsored through Pfizer, after inseparable year the figure of persistent abstinence was 10% in the interest placebo, 15% instead of bupropion and 23% to go to varenicline.[1 - In a 2009 meta-analysis of 101 studies funded near Pfizer, varenicline was found to be more effectual than bupropion (odds ratio 1.40) and NRTs (odds proportion 1.56).[2 -
A Cochrane planned notice concluded that varenicline improved the strong of successfully quitting smoking by two- to three-fold proportionate to pharmacologically unassisted attempts. Varenicline was more serviceable than bupropion in this regard but not statistically upper to NRT.[3 -
The FDA has approved the ingest of varenicline on up to twelve weeks. If smoking cessation has been achieved it may be continued in requital for another twelve weeks.[4 -
Varenicline has not been tested in those junior to 18 years prehistoric or preggers women and therefore is not recommended in behalf of abuse at near these groups.
Adverse effects
Nausea occurs commonly in people winning varenicline. Other less plain side effects classify trouble, fix sleeping, and abnormal dreams. Rare side effects reported via people taking varenicline compared to placebo cover variation in discrimination, vomiting,abdominal tribulation, flatulence, and constipation. In a just out meta-analysis ownership papers at near Leung et al., it has been estimated that instead of every five subjects delightful varenicline at conservation doses (1 mg twice common), there will be an actuality of nausea, and for every 24 and 35 treated subjects, there will-power be an event of constipation and flatulence respectively. Gastrointestinal side-effects are important factors compromising the compliance of varenicline.[5 - [6 -
Despair and suicide
In November 2007, the FDA announced it had received post-marketing reports that patients using varenicline as a service to smoking cessation had accomplished various important side-effects, including suicidal ideation and occasional suicidal behavior, weird behavior, and drowsiness. On February 1, 2008 the FDA issued an active to fresh shed its findings, noting that "it appears increasingly plausible that there is an intimacy between Chantix and not joking neuropsychiatric symptoms". It is unidentified whether the psychiatric symptoms are related to the psychedelic or to nicotine withdrawal symptoms,[citation needed - although not all patients had stopped smoking. The FDA also recommended that health care professionals and patients ready for for behavioral and eager changes.[7 - In May 2008, Pfizer updated the safety information associated with varenicline, noting that "some patients have reported changes in behavior, agitation, depressed mood, suicidal thoughts or actions."[8 -
As of July 1, 2009, the US Edibles and Hypnotic Direction requires Chantix (varenicline) to lug a black crate notice, the agency's strongest security notice, proper to viewable reports of side effects including concavity, suicidal thoughts, and suicidal actions.[9 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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